Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries

Michio Kurosu, Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.

Original languageEnglish (US)
Pages (from-to)339-352
Number of pages14
JournalHeterocycles
Volume72
DOIs
StatePublished - Apr 13 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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