TY - JOUR
T1 - Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines
AU - On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO)
AU - Hong, Catherine H.L.
AU - Gueiros, Luiz Alcino
AU - Fulton, Janet S.
AU - Cheng, Karis Kin Fong
AU - Kandwal, Abhishek
AU - Galiti, Dimitra
AU - Fall-Dickson, Jane M.
AU - Johansen, Jorgen
AU - Ameringer, Suzanne
AU - Kataoka, Tomoko
AU - Weikel, Dianna
AU - Eilers, June
AU - Ranna, Vinasha
AU - Vaddi, Anusha
AU - Lalla, Rajesh V.
AU - Bossi, Paolo
AU - Elad, Sharon
N1 - Funding Information:
The authors would like to gratefully acknowledge Mr. Eyal Zur, BSc Pharm, RPh, MBA, for the calculations of the hydrogen peroxide and sodium bicarbonate concentrations under the bland mouth rinses in the results section.The authors are also thankful for the medical librarians for their valuable contribution to this project: Lorraine Porcello, MSLIS, MSIM – Bibby Dental Library, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA; Daniel A. Castillo, MLIS – Edward G. Miner Library, University of Rochester Medical Center, Rochester, NY, USA.
Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Purpose: The aim of this study was to update the clinical practice guidelines for the use of basic oral care (BOC) interventions for the prevention and/or treatment of oral mucositis (OM). Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention in each cancer treatment setting was assigned an evidence level. The findings were added to the database used to develop the 2013 MASCC/ISOO clinical practice guidelines. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results: A total of 17 new papers across six interventions were examined and merged with a previous database. Based on the literature, the following guidelines were possible. The panel suggests that the implementation of multi-agent combination oral care protocols is beneficial for the prevention of OM during chemotherapy, head and neck (H&N) radiation therapy (RT), and hematopoietic stem cell transplantation (Level of Evidence III). The panel suggests that chlorhexidine not be used to prevent OM in patients undergoing H&N RT (Level of Evidence III). No guideline was possible for professional oral care, patient education, saline, and sodium bicarbonate, and expert opinion complemented these guidelines. Conclusions: The evidence supports the use of multi-agent combination oral care protocols in the specific populations listed above. Additional well-designed research is needed on the other BOC interventions prior to guideline formulation.
AB - Purpose: The aim of this study was to update the clinical practice guidelines for the use of basic oral care (BOC) interventions for the prevention and/or treatment of oral mucositis (OM). Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention in each cancer treatment setting was assigned an evidence level. The findings were added to the database used to develop the 2013 MASCC/ISOO clinical practice guidelines. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results: A total of 17 new papers across six interventions were examined and merged with a previous database. Based on the literature, the following guidelines were possible. The panel suggests that the implementation of multi-agent combination oral care protocols is beneficial for the prevention of OM during chemotherapy, head and neck (H&N) radiation therapy (RT), and hematopoietic stem cell transplantation (Level of Evidence III). The panel suggests that chlorhexidine not be used to prevent OM in patients undergoing H&N RT (Level of Evidence III). No guideline was possible for professional oral care, patient education, saline, and sodium bicarbonate, and expert opinion complemented these guidelines. Conclusions: The evidence supports the use of multi-agent combination oral care protocols in the specific populations listed above. Additional well-designed research is needed on the other BOC interventions prior to guideline formulation.
KW - Basic oral care
KW - Cancer
KW - Chlorhexidine
KW - Dental care
KW - Guidelines
KW - Oral mucositis
KW - Patient education
KW - Saline
KW - Sodium bicarbonate
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U2 - 10.1007/s00520-019-04848-4
DO - 10.1007/s00520-019-04848-4
M3 - Article
C2 - 31286232
AN - SCOPUS:85068824989
VL - 27
SP - 3949
EP - 3967
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
SN - 0941-4355
IS - 10
ER -