TY - JOUR
T1 - Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study
AU - Linder, J.
AU - Croker, B. P.
AU - Vollmer, R. T.
AU - Shelburne, J.
PY - 1983
Y1 - 1983
N2 - This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobulin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.
AB - This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobulin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.
UR - http://www.scopus.com/inward/record.url?scp=0020657149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020657149&partnerID=8YFLogxK
U2 - 10.1097/00000478-198301000-00009
DO - 10.1097/00000478-198301000-00009
M3 - Article
C2 - 6402947
AN - SCOPUS:0020657149
SN - 0147-5185
VL - 7
SP - 85
EP - 93
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 1
ER -