Systems and synthetic biology of the vessel wall

Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.

Original languageEnglish (US)
Pages (from-to)2164-2170
Number of pages7
JournalFEBS Letters
Volume586
Issue number15
DOIs
StatePublished - Jul 16 2012

Keywords

  • Mechanotransduction
  • Synthetic biology
  • Systems medicine
  • Vascular

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Frueh, J., Maimari, N., Lui, Y., Kis, Z., Mehta, V., Pormehr, N., Grant, C., Chalkias, E., Falck-Hansen, M., Bovens, S., Pedrigi, R., Homma, T., Coppola, G., & Krams, R. (2012). Systems and synthetic biology of the vessel wall. FEBS Letters, 586(15), 2164-2170. https://doi.org/10.1016/j.febslet.2012.04.031