Tailored electrospun small-diameter graft for vascular prosthesis

Pier Francesco Ferrari, Bahar Aliakbarian, Alberto Lagazzo, Ali Tamayol, Domenico Palombo, Patrizia Perego

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

There is an unmet need for engineering small vascular graft that can be anastomosed without inducing thrombosis. The objective of this work is to fabricate tubular graft with 2 mm of diameter with biomimetic mechanical and biological properties. Poly(ε-caprolactone) and poly(glycerol sebacate) blends with different concentrations and ratios are used to fabricate fibrous grafts using electrospinning process. Porous and degradable scaffolds with enhanced mechanical properties and comparable suture retention to the native human artery are fabricated. Scaffold–blood interaction revealed good anticoagulation properties. The fabricated constructs can serve as biocompatible and hemocompatible vascular graft with enhanced mechanical properties.

Original languageEnglish (US)
Pages (from-to)635-643
Number of pages9
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume66
Issue number12
DOIs
StatePublished - Aug 13 2017
Externally publishedYes

Keywords

  • Electrospun graft
  • hemocompatibility
  • poly(glycerol sebacate):poly(ε-caprolactone) (PGS–PCL)
  • vascular prosthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Polymers and Plastics

Fingerprint Dive into the research topics of 'Tailored electrospun small-diameter graft for vascular prosthesis'. Together they form a unique fingerprint.

  • Cite this