Tailoring the spatial filament organization within nanofibrous tissue engineering scaffolds

Neda Shah Hosseini, Nimet Bölgen, Nabyl Khenoussi, Seda Ceylan, Dilek Göktürk, Laurence Schacher, Dominique Adolphe, Ali Tamayol

Research output: Contribution to journalArticle

Abstract

Fabricating scaffolds with biomimetic architectures is an important step toward engineering functional tissues. Electrospinning is a popular approach for creating nanofibrous substrates in which the filaments resembling the natural extracellular matrix (ECM) can provide topographical cues to cells directing their growth. One of the major challenges in electrospinning is tailoring the spatial organization of the filaments. To overcome this challenge, a hybrid static collector was utilized to form distinct filament organizations. The filament organization was characterized using image processing based on the Fourier Transforms Method. The effect of different filament orientation ratios on cellular growth is discussed.

Keywords

  • Electrospinning
  • hybrid collector
  • spatial filament organization
  • tissue interfaces

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Polymers and Plastics

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