Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma

Ashkan Lashkari, Warren A. Chow, Frances Valdes, Lucille Leong, Vu Phan, Przemyslaw Twardowski, Neena Kapoor, Arturo Molina, Zaid Al-Kadhimi, Paul Frankel, George Somlo

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Patients with locally advanced or metastatic/recurrent soft tissue and Ewing's sarcoma (EWS) have few treatment options. The purpose of our phase II study was to assess the feasibility, safety and efficacy of tandem high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) in such patients. Patients and Methods: Thirteen patients were enrolled onto this study. The first cycle of HDCT consisted of doxorubicin (150 mg/m 2) and ifosfamide (14 g/m2) mixed with mesna (14 g/m 2), while the second cycle consisted of melphalan (150 mg/m 2) and cisplatin (200 mg/m2). Results: Eleven out of 13 patients were able to complete both cycles of HDCT. No treatment-related mortality occurred and grade 3 or 4 toxicity was clinically tolerable. The 5-year progression-free survival (PFS) and overall survival (OS) for all patients was 23% (confidence interval, CI: 0-46%) and 31% (CI: 14-70%), respectively. Out of the four patients still alive, two had EWS and measurable disease at the time of ASCT and achieved a complete remission, remaining progression free 126 and 155 months after ASCT. Conclusion: Our study demonstrates the feasibility and safety of tandem HDCT in patients with high-risk or metastatic/recurrent sarcoma, with some patients achieving long-term PFS and OS.

Original languageEnglish (US)
Pages (from-to)3281-3288
Number of pages8
JournalAnticancer Research
Volume29
Issue number8
StatePublished - Aug 2009

Keywords

  • Autologous transplantation
  • Ewing's sarcoma
  • High-dose chemotherapy
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Lashkari, A., Chow, W. A., Valdes, F., Leong, L., Phan, V., Twardowski, P., Kapoor, N., Molina, A., Al-Kadhimi, Z., Frankel, P., & Somlo, G. (2009). Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma. Anticancer Research, 29(8), 3281-3288.