Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A-E

Yan Liu, Haoxin Wang, Rentai Song, Jining Chen, Tianhong Li, Yaoyao Li, Liangcheng Du, Yuemao Shen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Polycyclic tetramate macrolactams (PoTeMs) are a growing class of natural products with distinct structure and diverse biological activities. By promoter engineering and heterologous expression of the cryptic cbm gene cluster, four new PoTeMs, combamides A-E (1-4), were identified. Additionally, two new derivatives, combamides E (5) and F (6), were generated via combinatorial biosynthesis. Together, our findings provide a sound base for expanding the structure diversities of PoTeMs through genome mining and combinatorial biosynthesis.

Original languageEnglish (US)
Pages (from-to)3504-3508
Number of pages5
JournalOrganic Letters
Volume20
Issue number12
DOIs
StatePublished - Jun 15 2018

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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