Targeted therapy for squamous cell carcinoma of the head and neck.

Ibrahim T. Aldoss, Apar Kishor Ganti

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Targeted agents have emerged as novel drugs in the oncology field based on our understanding of the biology of individual malignancies, and have had a promising impact in several tumors. Squamous cell carcinoma of the head and neck (SCCHN) is a common disease with little progress made in survival over the past few decades. SCCHN is characterized by overexpression of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF), both of which appear to have a prognostic value. Hence these receptors and their downstream pathways make attractive therapeutic targets. This review discusses targeted therapies currently being evaluated for their role in squamous cell carcinoma of the head and neck.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalJournal of the Egyptian National Cancer Institute
Volume21
Issue number2
StatePublished - Jun 2009

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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