Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

Siddappa N. Byrareddy, Brianne Kallam, James Arthos, Claudia Cicala, Fatima Nawaz, Joseph Hiatt, Ellen N. Kersh, Janet M. McNicholl, Debra Hanson, Keith A. Reimann, Markus Brameier, Lutz Walter, Kenneth Rogers, Ann E. Mayne, Paul Dunbar, Tara Villinger, Dawn Little, Tristram G. Parslow, Philip J. Santangelo, Francois VillingerAnthony S. Fauci, Aftab A. Ansari

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

α4β7 integrin-expressing CD4+ T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α4β7 monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIV mac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4+ T cell numbers were maintained in both the blood and the GALT. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques.

Original languageEnglish (US)
Pages (from-to)1397-1400
Number of pages4
JournalNature Medicine
Volume20
Issue number12
DOIs
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Targeting α<sub>4</sub>β<sub>7</sub> integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection'. Together they form a unique fingerprint.

Cite this