Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

Siddappa N. Byrareddy; Brianne Kallam; James Arthos; Claudia Cicala; Fatima Nawaz; Joseph Hiatt; Ellen N. Kersh; Janet M. McNicholl; Debra Hanson; Keith A. Reimann; Markus Brameier; Lutz Walter; Kenneth Rogers; Ann E. Mayne; Paul Dunbar; Tara Villinger; Dawn Little; Tristram G. Parslow; Philip J. Santangelo; Francois Villinger; Anthony S. Fauci; Aftab A. Ansari

doi:10.1038/nm.3715

Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

Siddappa N. Byrareddy, Brianne Kallam, James Arthos, Claudia Cicala, Fatima Nawaz, Joseph Hiatt, Ellen N. Kersh, Janet M. McNicholl, Debra Hanson, Keith A. Reimann, Markus Brameier, Lutz Walter, Kenneth Rogers, Ann E. Mayne, Paul Dunbar, Tara Villinger, Dawn Little, Tristram G. Parslow, Philip J. Santangelo, Francois VillingerAnthony S. Fauci, Aftab A. Ansari

Research output: Contribution to journal › Article

87 Scopus citations

Abstract

α₄β₇ integrin-expressing CD4⁺ T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α₄β₇ monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIV mac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4⁺ T cell numbers were maintained in both the blood and the GALT. Thus, targeting α₄β₇ reduces mucosal transmission of SIV in macaques.

Original language	English (US)
Pages (from-to)	1397-1400
Number of pages	4
Journal	Nature Medicine
Volume	20
Issue number	12
DOIs	https://doi.org/10.1038/nm.3715
State	Published - Dec 1 2014

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1038/nm.3715

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Byrareddy, S. N., Kallam, B., Arthos, J., Cicala, C., Nawaz, F., Hiatt, J., Kersh, E. N., McNicholl, J. M., Hanson, D., Reimann, K. A., Brameier, M., Walter, L., Rogers, K., Mayne, A. E., Dunbar, P., Villinger, T., Little, D., Parslow, T. G., Santangelo, P. J., ... Ansari, A. A. (2014). Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. Nature Medicine, 20(12), 1397-1400. https://doi.org/10.1038/nm.3715

Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. / Byrareddy, Siddappa N.; Kallam, Brianne; Arthos, James; Cicala, Claudia; Nawaz, Fatima; Hiatt, Joseph; Kersh, Ellen N.; McNicholl, Janet M.; Hanson, Debra; Reimann, Keith A.; Brameier, Markus; Walter, Lutz; Rogers, Kenneth; Mayne, Ann E.; Dunbar, Paul; Villinger, Tara; Little, Dawn; Parslow, Tristram G.; Santangelo, Philip J.; Villinger, Francois; Fauci, Anthony S.; Ansari, Aftab A.

In: Nature Medicine, Vol. 20, No. 12, 01.12.2014, p. 1397-1400.

Research output: Contribution to journal › Article

Byrareddy, SN, Kallam, B, Arthos, J, Cicala, C, Nawaz, F, Hiatt, J, Kersh, EN, McNicholl, JM, Hanson, D, Reimann, KA, Brameier, M, Walter, L, Rogers, K, Mayne, AE, Dunbar, P, Villinger, T, Little, D, Parslow, TG, Santangelo, PJ, Villinger, F, Fauci, AS & Ansari, AA 2014, 'Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection', Nature Medicine, vol. 20, no. 12, pp. 1397-1400. https://doi.org/10.1038/nm.3715

Byrareddy, Siddappa N. ; Kallam, Brianne ; Arthos, James ; Cicala, Claudia ; Nawaz, Fatima ; Hiatt, Joseph ; Kersh, Ellen N. ; McNicholl, Janet M. ; Hanson, Debra ; Reimann, Keith A. ; Brameier, Markus ; Walter, Lutz ; Rogers, Kenneth ; Mayne, Ann E. ; Dunbar, Paul ; Villinger, Tara ; Little, Dawn ; Parslow, Tristram G. ; Santangelo, Philip J. ; Villinger, Francois ; Fauci, Anthony S. ; Ansari, Aftab A. / Targeting α₄β₇ integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. In: Nature Medicine. 2014 ; Vol. 20, No. 12. pp. 1397-1400.

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