Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance

Joshua J. Souchek, Lindsey Muraskin, Lucas Houser, Quyen Vu, Aaron M. Mohs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aberrant metabolism mechanisms are a well-established hallmark of cancer. Exploiting tumor metabolism as a therapeutic target is being actively pursued. De novo synthesis of fatty acids by fatty acid synthase (FASN) is a particularly attractive mechanism to target because increased lipid synthesis is associated with more aggressive tumor. In particular, our work focuses on the reformulation of orlistat, an FDA-approved lipase inhibitor that also inhibits the thioesterase domain of FASN. We report on the rationale, synthesis, efficacy, delivery, and limitations of a novel nanoparticle formulation of orlistat in the goal of targeting the FASN pathway.

Original languageEnglish (US)
Title of host publicationVisualizing and Quantifying Drug Distribution in Tissue III
EditorsKin Foong Chan, Conor L. Evans
PublisherSPIE
ISBN (Electronic)9781510623606
DOIs
StatePublished - 2019
EventVisualizing and Quantifying Drug Distribution in Tissue III 2019 - San Francisco, United States
Duration: Feb 2 2019 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10859
ISSN (Print)1605-7422

Conference

ConferenceVisualizing and Quantifying Drug Distribution in Tissue III 2019
CountryUnited States
CitySan Francisco
Period2/2/19 → …

Keywords

  • Chemoresistance
  • Drug delivery
  • Fatty acid synthase (FASN)
  • Hyaluronic acid
  • Lipogenesis
  • Nanoparticle
  • Synergy
  • Tumor metabolism

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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