@inproceedings{b9b149640cf94bc9945cbd1d859a637e,
title = "Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance",
abstract = "Aberrant metabolism mechanisms are a well-established hallmark of cancer. Exploiting tumor metabolism as a therapeutic target is being actively pursued. De novo synthesis of fatty acids by fatty acid synthase (FASN) is a particularly attractive mechanism to target because increased lipid synthesis is associated with more aggressive tumor. In particular, our work focuses on the reformulation of orlistat, an FDA-approved lipase inhibitor that also inhibits the thioesterase domain of FASN. We report on the rationale, synthesis, efficacy, delivery, and limitations of a novel nanoparticle formulation of orlistat in the goal of targeting the FASN pathway.",
keywords = "Chemoresistance, Drug delivery, Fatty acid synthase (FASN), Hyaluronic acid, Lipogenesis, Nanoparticle, Synergy, Tumor metabolism",
author = "Souchek, {Joshua J.} and Lindsey Muraskin and Lucas Houser and Quyen Vu and Mohs, {Aaron M.}",
note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; Visualizing and Quantifying Drug Distribution in Tissue III 2019 ; Conference date: 02-02-2019",
year = "2019",
doi = "10.1117/12.2512244",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Chan, {Kin Foong} and Evans, {Conor L.}",
booktitle = "Visualizing and Quantifying Drug Distribution in Tissue III",
}