Targeting matrix remodeling in cardiac hypertrophy and heart failure

Merry L. Lindsey; Francis G. Spinale

doi:10.1016/j.ddstr.2005.08.001

Targeting matrix remodeling in cardiac hypertrophy and heart failure

Merry L. Lindsey, Francis G. Spinale

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Chronic pressure overload, such as that with hypertension, induces left ventricular (LV) remodeling characterized by increased mass, that is, LV hypertrophy (LVH). LVH can cause impaired diastolic function and thereby contribute to heart failure. The myocardial extracellular matrix undergoes significant remodeling in LVH contributing to abnormalities in diastolic function. Current pharmacological strategies for the treatment of hypertension only indirectly and/or incompletely affect the structure and composition of the myocardial matrix. Identifying crucial pathways involved in matrix remodeling in hypertension-induced LVH will aid in the selection of more relevant targets.

Original language	English (US)
Pages (from-to)	253-258
Number of pages	6
Journal	Drug Discovery Today: Therapeutic Strategies
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.ddstr.2005.08.001
State	Published - 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

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abstract = "Chronic pressure overload, such as that with hypertension, induces left ventricular (LV) remodeling characterized by increased mass, that is, LV hypertrophy (LVH). LVH can cause impaired diastolic function and thereby contribute to heart failure. The myocardial extracellular matrix undergoes significant remodeling in LVH contributing to abnormalities in diastolic function. Current pharmacological strategies for the treatment of hypertension only indirectly and/or incompletely affect the structure and composition of the myocardial matrix. Identifying crucial pathways involved in matrix remodeling in hypertension-induced LVH will aid in the selection of more relevant targets.",

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AB - Chronic pressure overload, such as that with hypertension, induces left ventricular (LV) remodeling characterized by increased mass, that is, LV hypertrophy (LVH). LVH can cause impaired diastolic function and thereby contribute to heart failure. The myocardial extracellular matrix undergoes significant remodeling in LVH contributing to abnormalities in diastolic function. Current pharmacological strategies for the treatment of hypertension only indirectly and/or incompletely affect the structure and composition of the myocardial matrix. Identifying crucial pathways involved in matrix remodeling in hypertension-induced LVH will aid in the selection of more relevant targets.

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