Techniques to stimulate and interrogate cell–cell adhesion mechanics

Ruiguo Yang, Joshua A. Broussard, Kathleen J. Green, Horacio D. Espinosa

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Cell–cell adhesions maintain the mechanical integrity of multicellular tissues and have recently been found to act as mechanotransducers, translating mechanical cues into biochemical signals. Mechanotransduction studies have primarily focused on focal adhesions, sites of cell-substrate attachment. These studies leverage technical advances in devices and systems interfacing with living cells through cell–extracellular matrix adhesions. As reports of aberrant signal transduction originating from mutations in cell–cell adhesion molecules are being increasingly associated with disease states, growing attention is being paid to this intercellular signaling hub. Along with this renewed focus, new requirements arise for the interrogation and stimulation of cell–cell adhesive junctions. This review covers established experimental techniques for stimulation and interrogation of cell–cell adhesion from cell pairs to monolayers.

Original languageEnglish (US)
Pages (from-to)125-139
Number of pages15
JournalExtreme Mechanics Letters
Volume20
DOIs
StatePublished - Apr 2018

Keywords

  • BioMEMS
  • Cell mechanics
  • Cell–cell adhesion
  • FRET
  • Mechanobiology

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Engineering (miscellaneous)
  • Mechanics of Materials
  • Mechanical Engineering

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