TY - JOUR
T1 - Telomerase
T2 - Diagnostics, cancer therapeutics and tissue engineering
AU - Ouellette, Michel M.
AU - Lee, Kwangmoon
PY - 2001/12/1
Y1 - 2001/12/1
N2 - The enzyme telomerase has a key role in controlling the lifespan of human cells. It is absent from most somatic tissues but is reactivated in more than 85% of cancers, making the enzyme ideal as a marker of cancer cells and as a therapeutic target. In the context of normal human cells, the enzyme can extend cellular lifespan without causing cancer-associated changes or altering phenotypic properties. This capability could solve a major obstacle in the use of normal human cells for tissue engineering, that is, the induction of cellular senescence.
AB - The enzyme telomerase has a key role in controlling the lifespan of human cells. It is absent from most somatic tissues but is reactivated in more than 85% of cancers, making the enzyme ideal as a marker of cancer cells and as a therapeutic target. In the context of normal human cells, the enzyme can extend cellular lifespan without causing cancer-associated changes or altering phenotypic properties. This capability could solve a major obstacle in the use of normal human cells for tissue engineering, that is, the induction of cellular senescence.
UR - http://www.scopus.com/inward/record.url?scp=0035576854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035576854&partnerID=8YFLogxK
U2 - 10.1016/S1359-6446(01)02052-9
DO - 10.1016/S1359-6446(01)02052-9
M3 - Review article
AN - SCOPUS:0035576854
SN - 1359-6446
VL - 6
SP - 1231
EP - 1237
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 23
ER -