Les telomeres et le vieillissement des cellules

Translated title of the contribution: Telomere-controlled senescence

Michel M. Ouellette, Isabelle Savre-Train

Research output: Contribution to journalShort surveypeer-review

11 Scopus citations


Most normal human cells have a finite life span. After a limited number of cell divisions, they reach a quiescent state termed senescence. During this process, cell cycle progression is blocked by the activation of p53 and the induction of p16(INK4a). The onset of senescence is controlled by the shortening of telomeres that occurs each time normal human cells divide. The observation that telomeres shortening occurs in vivo suggests that senescence may play a role in the aging process. The enzyme telomerase can extend the life span of human cells by synthesizing new telomeric DNA. This enzyme, absent from most somatic tissues, contains an RNA (hTR) that serves as a template for the synthesis of telomeric DNA and a reverse transcriptase (hTERT) that provides catalytic activity. The forced expression of exogenous hTERT in normal human cells is sufficient to reconstitute telomerase activity, maintain the size of telomere and prevent the induction of senescence. During carcinogenesis, senescence is frequently inhibited by the ectopic expression of telomerase. Although senescence might be detrimental as a potential cause of aging, its evolutionary advantage is to provide an additional obstacle to the development of cancers.

Translated title of the contributionTelomere-controlled senescence
Original languageFrench
Pages (from-to)473-480
Number of pages8
Issue number4
StatePublished - Apr 2000

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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