Template-assisted synthesis of nanogels from Pluronic-modified poly(acrylic acid)

Tatiana K. Bronich, Satya Bontha, Luda S. Shlyakhtenko, Lev Bromberg, T. Alan Hatton, Alexander V. Kabanov

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

A series of novel polymeric nanogels with core-shell morphology was developed. Block ionomer complexes of comb-graft poly(ethylene oxide)-b-poly(polypropylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid) copolymers (Pluronic-PAA) and divalent metal cations were utilized as micellar templates for the synthesis of nanogels with sizes ranging from 100 to 200 nm in diameter. The Pluronic-PAA nanogels were confirmed to possess ionic cross-linked PAA cores and flexible hydrophilic shells from the Pluronic copolymer chains. The ionic character of the core provided for pH-dependent swelling/collapse behavior of the nanogels. These prepared nanogels are expected to be of utility as carriers for charged therapeutic or diagnostic agents.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalJournal of Drug Targeting
Volume14
Issue number6
DOIs
StatePublished - Jul 2006

Keywords

  • Block copolymer
  • Core-shell morphology
  • Micelles
  • Nanogels
  • Pluronic and poly(acrylic acid) copolymers template assembly

ASJC Scopus subject areas

  • Pharmaceutical Science

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