Abstract
A series of novel polymeric nanogels with core-shell morphology was developed. Block ionomer complexes of comb-graft poly(ethylene oxide)-b-poly(polypropylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid) copolymers (Pluronic-PAA) and divalent metal cations were utilized as micellar templates for the synthesis of nanogels with sizes ranging from 100 to 200 nm in diameter. The Pluronic-PAA nanogels were confirmed to possess ionic cross-linked PAA cores and flexible hydrophilic shells from the Pluronic copolymer chains. The ionic character of the core provided for pH-dependent swelling/collapse behavior of the nanogels. These prepared nanogels are expected to be of utility as carriers for charged therapeutic or diagnostic agents.
Original language | English (US) |
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Pages (from-to) | 357-366 |
Number of pages | 10 |
Journal | Journal of Drug Targeting |
Volume | 14 |
Issue number | 6 |
DOIs | |
State | Published - Jul 2006 |
Keywords
- Block copolymer
- Core-shell morphology
- Micelles
- Nanogels
- Pluronic and poly(acrylic acid) copolymers template assembly
ASJC Scopus subject areas
- Pharmaceutical Science