TY - JOUR
T1 - Template free synthesis of mesoporous hectorites
T2 - Efficient host for pH responsive drug delivery
AU - Pawar, Radheshyam R.
AU - Kevadiya, Bhavesh D.
AU - Brahmbhatt, Harshad
AU - Bajaj, Hari C.
N1 - Funding Information:
The authors are thankful to the Council of Scientific & Industrial Research (CSIR) for financial support through network project NWP-0010. They are also thankful to the Analytical Department and Centralized Instrument Facility, CSMCRI for providing assistance. RRP and BK thanks CSIR, New Delhi for the award of Senior Research Fellowship.
PY - 2013/3/25
Y1 - 2013/3/25
N2 - The organized mesoporous matrices with large surface area and large pore volumes are potential drug carriers and hence find good applications in the field of controlled and sustained drug delivery. Two novel mesoporous synthetic hectorite (MSH) materials, namely, MSH3 and MSH4 with diverse composition and pore performance have been synthesized by a template free route and studied for the controlled drug delivery applications. MSH3 with 0.14LiF:5.93 Mg(OH) 2:8 SiO2 synthetic composition exhibited higher quinine adsorption than that by MSH4 (2.8LiF:4.6 Mg(OH)2:8SiO2). In vitro studies at 37 ± 0.5 °C temperature under sequential buffer conditions showed controlled drug release with respect to the variation in pH values while following Eudragit VR L100 coated gelatin capsules; however, dialysis bag technique do not show such pH controlled delivery. Kinetic data suggest the release of QUI from the nanocomposite follows dissolution diffusion model.
AB - The organized mesoporous matrices with large surface area and large pore volumes are potential drug carriers and hence find good applications in the field of controlled and sustained drug delivery. Two novel mesoporous synthetic hectorite (MSH) materials, namely, MSH3 and MSH4 with diverse composition and pore performance have been synthesized by a template free route and studied for the controlled drug delivery applications. MSH3 with 0.14LiF:5.93 Mg(OH) 2:8 SiO2 synthetic composition exhibited higher quinine adsorption than that by MSH4 (2.8LiF:4.6 Mg(OH)2:8SiO2). In vitro studies at 37 ± 0.5 °C temperature under sequential buffer conditions showed controlled drug release with respect to the variation in pH values while following Eudragit VR L100 coated gelatin capsules; however, dialysis bag technique do not show such pH controlled delivery. Kinetic data suggest the release of QUI from the nanocomposite follows dissolution diffusion model.
KW - Drug delivery
KW - Eudragit VR L100
KW - Mesoporous synthetic hectorites
KW - Pore engineering
KW - Quinine hydrochloride dihydrate
KW - Template free synthesis
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U2 - 10.1016/j.ijpharm.2013.02.021
DO - 10.1016/j.ijpharm.2013.02.021
M3 - Article
C2 - 23419664
AN - SCOPUS:84874639195
SN - 0378-5173
VL - 446
SP - 145
EP - 152
JO - International journal of pharmaceutics
JF - International journal of pharmaceutics
IS - 1-2
ER -