Temporal lobe epilepsy: A progressive disorder?

Katherine Nearing, Deepak Madhavan, Orrin Devinsky

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Temporal lobe epilepsy (TLE) can be a progressive disorder, potentially resulting in structural damage and a decline of cognitive abilities over time. This is particularly evident in cases that are refractory to medication. This review examines the changes that occur in refractory TLE over time and the factors associated with these changes. Imaging and histologic studies on the brains of patients with TLE reveal anatomic and metabolic changes associated with continued seizures. These changes can impair cognitive and behavioral function. Seizure control may help minimize or prevent these changes.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalReviews in Neurological Diseases
Issue number3
StatePublished - Jun 2007
Externally publishedYes


  • Progressive disorders
  • Seizure control
  • Seizures
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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