@article{8e7115dee1e04326b3778ce1a3f62616,
title = "Temporal lobe regions essential for preserved picture naming after left temporal epilepsy surgery",
abstract = "Objective: To define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects. Methods: Pre- and postoperative brain magnetic resonance imaging data and picture naming (Boston Naming Test) scores were obtained prospectively from 59 people with drug-resistant left temporal lobe epilepsy. All patients had left hemisphere language dominance at baseline and underwent surgical resection or ablation in the left temporal lobe. Postoperative naming assessment occurred approximately 7 months after surgery. Surgical lesions were mapped to a standard template, and the relationship between presence or absence of a lesion and the degree of naming decline was tested at each template voxel while controlling for effects of overall lesion size. Results: Patients declined by an average of 15% in their naming score, with wide variation across individuals. Decline was significantly related to damage in a cluster of voxels in the ventral temporal lobe, located mainly in the fusiform gyrus approximately 4-6 cm posterior to the temporal tip. Extent of damage to this region explained roughly 50% of the variance in outcome. Picture naming decline was not related to hippocampal or temporal pole damage. Significance: The results provide the first statistical map relating lesion location in left temporal lobe epilepsy surgery to picture naming decline, and they support previous observations of transient naming deficits from electrical stimulation in the basal temporal cortex. The critical lesion is relatively posterior and could be avoided in many patients undergoing left temporal lobe surgery for intractable epilepsy.",
keywords = "anomia, epilepsy, fusiform gyrus, lesion localization, temporal lobe",
author = "{FMRI in Anterior Temporal Epilepsy Surgery (FATES) study} and Binder, {Jeffrey R.} and Tong, {Jia Qing} and Pillay, {Sara B.} and Conant, {Lisa L.} and Humphries, {Colin J.} and Manoj Raghavan and Mueller, {Wade M.} and Busch, {Robyn M.} and Linda Allen and Gross, {William L.} and Anderson, {Christopher T.} and Carlson, {Chad E.} and Lowe, {Mark J.} and Langfitt, {John T.} and Tivarus, {Madalina E.} and Drane, {Daniel L.} and Loring, {David W.} and Monica Jacobs and Morgan, {Victoria L.} and Allendorfer, {Jane B.} and Szaflarski, {Jerzy P.} and Leonardo Bonilha and Susan Bookheimer and Thomas Grabowski and Jennifer Vannest and Swanson, {Sara J.} and Bassel Abou-Khalil and Ellen Air and Jeanette Albertson and Erik Beall and Michael Berg and William Bingaman and Brown, {Truman R.} and Cohen, {Nancy J.} and Noreen Connolly and Alex Dagley and Sheri Davis and Edwards, {Jonathan C.} and Lisa Ferguson and Glazier, {Steven S.} and Jorge Gonzalez-Martinez and Xiaoping Hu and Mirjana Ivanisevic and Colleen Kenney and Peter Konrad and Megan LeDoux and Lucy Mendoza and Katherine Murphy and Imad Najm and Vaishali Phatak",
note = "Funding Information: The study was supported by grant R01 NS35929 (J.R.B., Principal Investigator) from the National Institute of Neurological Disorders and Stroke. The authors thank the participating patients for their generous commitment of time and effort. We also thank the following individuals who assisted with the study as members of the FATES consortium: Bassel Abou‐Khalil, MD; Ellen Air, MD, PhD; Jeanette Albertson; Erik Beall, PhD; Michael Berg, MD; William Bingaman, MD; Truman R. Brown, PhD; Nancy J. Cohen; Noreen Connolly; Alex Dagley; Sheri Davis; Jonathan C. Edwards, MD; Lisa Ferguson; Steven S. Glazier, MD; Jorge Gonzalez‐Martinez, MD; Xiaoping Hu, PhD; Mirjana Ivanisevic; Colleen Kenney; Peter Konrad, MD, PhD; Megan LeDoux; Lucy Mendoza; Katherine Murphy; Imad Najm, MD; Andrew Nencka, PhD; Gloria Novak; Jeffrey Ojemann, MD; Vaishali Phatak, PhD; Webster Pilcher, MD; Michael Privitera, MD; Brian Renner; Kristen O. Riley, MD; Fred W. Sabb, PhD; Lisa Schwartz; Diane E. Smith; William A. Vandergrift III, MD; Mark Wagner, PhD; and Hwa Shain Yeh, MD. Publisher Copyright: {\textcopyright} 2020 International League Against Epilepsy",
year = "2020",
month = sep,
day = "1",
doi = "10.1111/epi.16643",
language = "English (US)",
volume = "61",
pages = "1939--1948",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "9",
}