Temporal lobe surgery in patients with normal MRI

Deepak Madhavan, Ruben Kuzniecky

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


PURPOSE OF REVIEW: The surgical approach to nonlesional temporal lobe epilepsy presents a significant challenge due to uncertainties regarding the extent of resection necessary to result in a seizure-free state. To outline an optimum surgical strategy, an understanding of the clinical and diagnostic presentation of mesial and lateral temporal epilepsy is required in order to properly characterize the location of the ictal onset zone. This review focuses on several methods used to identify this ictal onset zone, with emphasis on the impact each modality has on surgical outcome. RECENT FINDINGS: Factors predicting an excellent surgical outcome include the presence of a discrete zone of low voltage fast activity and prolonged propagation time on the electroencephalogram, and the absence of metabolic dysfunction in the contralateral temporal lobe. Identifying epileptogenic regions in the temporal lobe using magnetic source imaging is a recent technique that has also yielded promising surgical outcomes. Recent prospective studies have shown that a temporal neocortical resection is very effective in providing a seizure free outcome given strict localization of the ictal onset zone to the lateral temporal region, highlighting the need for accurate characterization of mesial versus lateral nonlesional epilepsy. SUMMARY: With accurate identification of the ictal onset zone with intracranial electroencephalography, a tailored temporal resection can yield excellent surgical results.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalCurrent Opinion in Neurology
Issue number2
StatePublished - Apr 2007


  • Intracranial EEG
  • Nonlesional
  • Surgical outcome
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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