Testing homogeneity in semiparametric mixture case–control models

Chong Zhi Di, Kwun Chuen Gary Chan, Cheng Zheng, Kung Yee Liang

Research output: Contribution to journalArticlepeer-review


Parametric and semiparametric mixture models have been widely used in applications from many areas, and it is often of interest to test the homogeneity in these models. However, hypothesis testing is non standard due to the fact that several regularity conditions do not hold under the null hypothesis. We consider a semiparametric mixture case–control model, in the sense that the density ratio of two distributions is assumed to be of an exponential form, while the baseline density is unspecified. This model was first considered by Qin and Liang (2011, biometrics), and they proposed a modified score statistic for testing homogeneity. In this article, we consider alternative testing procedures based on supremum statistics, which could improve power against certain types of alternatives. We demonstrate the connection and comparison among the proposed and existing approaches. In addition, we provide a unified theoretical justification of the supremum test and other existing test statistics from an empirical likelihood perspective. The finite-sample performance of the supremum test statistics was evaluated in simulation studies.

Original languageEnglish (US)
Pages (from-to)9092-9100
Number of pages9
JournalCommunications in Statistics - Theory and Methods
Issue number18
StatePublished - Sep 17 2017
Externally publishedYes


  • Case-control study
  • mixture models
  • semiparametric models

ASJC Scopus subject areas

  • Statistics and Probability


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