Abstract
When praziquantel was exposed to N-bromosuccinimide in the presence of ethanol, a tricyclic 3-bromo-1-ethoxy pyrazinone was formed. From this and the analogous 1,3-dibromopyrazinone, a small library of 3-alkylamino-1-ethoxy, 1,3-dialkoxy, 3-alkoxy-1-bromo, and 3-alkylamino-1-bromo substituted pyrazinones were synthesized in high yields.
Original language | English (US) |
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Pages (from-to) | 4463-4465 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 32 |
DOIs | |
State | Published - Aug 6 2014 |
Keywords
- N-Bromosuccinimide
- Piperazinone
- Praziquantel
- Pyrazinone
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry