TY - JOUR
T1 - The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays
AU - Preston, Bradley D.
AU - Miller, Elizabeth C.
AU - Miller, James A.
N1 - Funding Information:
We arc grateful to leva L.Reich for synthesis of the 2,2',5,5'-TCBO, to Amy Liem for the care of the animals, to Thomas L.Goldsworthy and H.A.Campbell for assistance in the quantitation of the hepatic 7-GT-positive foci, and to Craig B.Struble for assistance in the synthesis of the 2,2',4,4'-TCB. This work was supported by United States Public Health Service Grants CA-07175 and CA-22484 from the National Cancer Institute and 5-T-32-ES07015 from the National Institute of Environmental Health Sciences.
PY - 1985/3
Y1 - 1985/3
N2 - Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3, 4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic γ-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was ∼10-fold greater than that of the 2,2',5,5'-isomer.
AB - Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3, 4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic γ-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was ∼10-fold greater than that of the 2,2',5,5'-isomer.
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U2 - 10.1093/carcin/6.3.451
DO - 10.1093/carcin/6.3.451
M3 - Article
C2 - 2858273
AN - SCOPUS:0022389718
SN - 0143-3334
VL - 6
SP - 451
EP - 453
JO - Carcinogenesis
JF - Carcinogenesis
IS - 3
ER -