The activity of dispiro peroxides against Fasciola hepatica

Xiaofang Wang, Qingjie Zhao, Mireille Vargas, Yuxiang Dong, Kamaraj Sriraghavan, Jennifer Keiser, Jonathan L. Vennerstrom

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50 mg/kg and two were partially curative at single doses of 25 mg/kg.

Original languageEnglish (US)
Pages (from-to)5320-5323
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number18
StatePublished - Sep 15 2011


  • Artemisinin
  • Fasciola hepatica
  • Peroxide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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