The acute erythroleukemias

F. M. Mazzella, C. Alvares, A. Kowal-Vern, H. R. Schumacher

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Acute erythroleukemia is an aggressive leukemia derived from a multipotential stem cell. Three subtypes have been described: (1) M6a with greater than or equal to 30% blasts of the nonerythrocytic component, (2) M6b with greater than or equal to 30% pronormoblasts of the erythrocytic elements, and (3) M6c with greater than or equal to 30% blasts and greater than or equal to 30% pronormoblasts by the aforementioned exclusion criteria. The poor prognosis associated with this disorder positively correlates with a high pronormoblast:myeloblast ratio; unfavorable cytogenetic aberrations; a high proliferative index; and the presence of P-glycoprotein expression (multidrug resistance phenotype). Chemotherapeutic regimens directed toward these specific parameters should be devised in order to improve the characteristically poor outcome of this patient population.

Original languageEnglish (US)
Pages (from-to)119-137
Number of pages19
JournalClinics in Laboratory Medicine
Volume20
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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