TY - JOUR
T1 - The age-related trajectory of visual attention neural function is altered in adults living with HIV
T2 - A cross-sectional MEG study
AU - Arif, Yasra
AU - Wiesman, Alex I.
AU - O'Neill, Jennifer
AU - Embury, Christine
AU - May, Pamela E.
AU - Lew, Brandon J.
AU - Schantell, Mikki D.
AU - Fox, Howard S.
AU - Swindells, Susan
AU - Wilson, Tony W.
N1 - Funding Information:
This work was primarily supported by the National Institute of Mental Health ( MH103220 , MH116782 , MH118013 , and MH062261 ), the National Institute for aging ( AG055332 ), the National Institute of General Medical Sciences ( GM130447 ), the National Institute on Drug Abuse ( DA041917 , DA047828 , and DA048713 ), and the National Science Foundation (# 1539067 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
The authors would like to acknowledge the enormous contribution of Kevin R. Robertson, PhD, professor of neurology and director of the AIDS Neurological center at the University of North Carolina at Chapel Hill. Dr. Robertson designed and analyzed all the neuropsychological testing, and sadly died during the conduct of the study. We would also like to thank our participants for volunteering. This work was primarily supported by the National Institute of Mental Health (MH103220, MH116782, MH118013, and MH062261), the National Institute for aging (AG055332), the National Institute of General Medical Sciences (GM130447), the National Institute on Drug Abuse (DA041917, DA047828, and DA048713), and the National Science Foundation (#1539067). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
Dr. Swindells reports research grants to her institution from the National Institutes of Health and ViiV Healthcare, with the ViiV healthcare support being unrelated to this work. Dr. Fox reports grants from the National Institutes of Health and the Michael J. Fox Foundation. Ms. OˈNeill reports grants from the National Institutes of Health, National Science Foundation, Janssen Scientific, Gilead Science, and grants and personal fees from ViiV Healthcare; the support from Janssen Scientific, Gilead Science, and ViiV Healthcare was for projects separate from and outside of the submitted work. Drs. Wilson, Arif, and Wiesman report research grants to their institution from the National Institutes of Health and the National Science Foundation. Dr. May reports research grants to her institution from the National Institutes of Health. Mr. Lew, Ms. Embury, and Ms. Schantell report research grants to their institution from the National Institutes of Health and the National Science Foundation. There were no other financial, commercial or institutional conflicts of interests to report.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/11
Y1 - 2020/11
N2 - Background: Despite living a normal lifespan, at least 35% of persons with HIV (PWH) in resource-rich countries develop HIV-associated neurocognitive disorder (HAND). This high prevalence of cognitive decline may reflect accelerated ageing in PWH, but the evidence supporting an altered ageing phenotype in PWH has been mixed. Methods: We examined the impact of ageing on the orienting of visual attention in PWH using dynamic functional mapping with magnetoencephalography (MEG) in 173 participants age 22–72 years-old (94 uninfected controls, 51 cognitively-unimpaired PWH, and 28 with HAND). All MEG data were imaged using a state-of-the-art beamforming approach and neural oscillatory responses during attentional orienting were examined for ageing, HIV, and cognitive status effects. Findings: All participants responded slower during trials that required attentional reorienting. Our functional mapping results revealed HIV-by-age interactions in left prefrontal theta activity, alpha oscillations in the left parietal, right cuneus, and right frontal eye-fields, and left dorsolateral prefrontal beta activity (p<.005). Critically, within PWH, we observed a cognitive status-by-age interaction, which revealed that ageing impacted the oscillatory gamma activity serving attentional reorienting differently in cognitively-normal PWH relative to those with HAND in the left temporoparietal, inferior frontal gyrus, and right prefrontal cortices (p<.005). Interpretation: This study provides key evidence supporting altered ageing trajectories across vital attention circuitry in PWH, and further suggests that those with HAND exhibit unique age-related changes in the oscillatory dynamics serving attention function. Additionally, our neural findings suggest that age-related changes in PWH may serve a compensatory function. Funding: National Institutes of Health, USA.
AB - Background: Despite living a normal lifespan, at least 35% of persons with HIV (PWH) in resource-rich countries develop HIV-associated neurocognitive disorder (HAND). This high prevalence of cognitive decline may reflect accelerated ageing in PWH, but the evidence supporting an altered ageing phenotype in PWH has been mixed. Methods: We examined the impact of ageing on the orienting of visual attention in PWH using dynamic functional mapping with magnetoencephalography (MEG) in 173 participants age 22–72 years-old (94 uninfected controls, 51 cognitively-unimpaired PWH, and 28 with HAND). All MEG data were imaged using a state-of-the-art beamforming approach and neural oscillatory responses during attentional orienting were examined for ageing, HIV, and cognitive status effects. Findings: All participants responded slower during trials that required attentional reorienting. Our functional mapping results revealed HIV-by-age interactions in left prefrontal theta activity, alpha oscillations in the left parietal, right cuneus, and right frontal eye-fields, and left dorsolateral prefrontal beta activity (p<.005). Critically, within PWH, we observed a cognitive status-by-age interaction, which revealed that ageing impacted the oscillatory gamma activity serving attentional reorienting differently in cognitively-normal PWH relative to those with HAND in the left temporoparietal, inferior frontal gyrus, and right prefrontal cortices (p<.005). Interpretation: This study provides key evidence supporting altered ageing trajectories across vital attention circuitry in PWH, and further suggests that those with HAND exhibit unique age-related changes in the oscillatory dynamics serving attention function. Additionally, our neural findings suggest that age-related changes in PWH may serve a compensatory function. Funding: National Institutes of Health, USA.
KW - Ageing
KW - Attentional reorientation
KW - HIV
KW - Magnetoencephalography
KW - Validity effect
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U2 - 10.1016/j.ebiom.2020.103065
DO - 10.1016/j.ebiom.2020.103065
M3 - Article
C2 - 33099087
AN - SCOPUS:85093654360
VL - 61
JO - EBioMedicine
JF - EBioMedicine
SN - 2352-3964
M1 - 103065
ER -