The antimicrobial armamentarium

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The treatment of infectious complications in the cancer patient has evolved as a consequence of the developments in cancer chemotherapy, which significantly impair immune function. Broad-spectrum, single-agent antibiotics have replaced more cumbersome multidrug regimens for empiric coverage of fever and neutropenia in many institutions. The use of new, potent oral antibiotics may be a next step toward further simplifications. Several new antivirals have come into clinical use in the past decade, and reports of viral resistance to the standard agent, acyclovir, have come forth. Increasing experience with new (and older) antifungal and antiparasitic agents has given a better understanding of the use of these drugs for both prophylaxis and treatment. This overview includes a critical appraisal of the attributes and limitations of current antibiotics, antivirals, antifungals, and antiparasitic agents for the immunocompromised host.

Original languageEnglish (US)
Pages (from-to)813-839
Number of pages27
JournalHematology/Oncology Clinics of North America
Issue number4
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology

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