Abstract
[3H]Thymidine ([3H]TdR) incorporation into urothelial DNA of male neonatal rats was measured autoradiographically at birth and during the first 3 weeks of life. The rats were derived from control parents and those fed saccharin (1, 3, 5 and 7.5%) in the diet from before pregnancy. [3H]TdR incorporation was inhibited and there were more lightly labeled cells (compared with controls), in all the saccharin-exposed rats in a rough dose-dependent manner. The results, in comparison with controls, suggest that saccharin exposure in utero causes DNA damage in the neonatal urothelium manifesting as reduced thymidine incorporation and a greater proportion of lightly labeled cells.
Original language | English (US) |
---|---|
Pages (from-to) | 259-264 |
Number of pages | 6 |
Journal | Cancer Letters |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - Aug 1981 |
ASJC Scopus subject areas
- Oncology
- Cancer Research