The apparent inhibition of urothelial DNA synthesis in neonatal rats by dietary saccharin

Terence Lawson, Paul Hertzog

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

[3H]Thymidine ([3H]TdR) incorporation into urothelial DNA of male neonatal rats was measured autoradiographically at birth and during the first 3 weeks of life. The rats were derived from control parents and those fed saccharin (1, 3, 5 and 7.5%) in the diet from before pregnancy. [3H]TdR incorporation was inhibited and there were more lightly labeled cells (compared with controls), in all the saccharin-exposed rats in a rough dose-dependent manner. The results, in comparison with controls, suggest that saccharin exposure in utero causes DNA damage in the neonatal urothelium manifesting as reduced thymidine incorporation and a greater proportion of lightly labeled cells.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalCancer Letters
Volume13
Issue number3
DOIs
StatePublished - Aug 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The apparent inhibition of urothelial DNA synthesis in neonatal rats by dietary saccharin'. Together they form a unique fingerprint.

Cite this