The application of FAST-NMR for the identification of novel drug discovery targets

Robert Powers, Kelly A. Mercier, Jennifer C. Copeland

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

The continued success of genome sequencing projects has resulted in a wealth of information, but 40-50% of identified genes correspond to hypothetical proteins or proteins of unknown function. The functional annotation screening technology by NMR (FAST-NMR) screen was developed to assign a biological function for these unannotated proteins with a structure solved by the protein structure initiative. FAST-NMR is based on the premise that a biological function can be described by a similarity in binding sites and ligand interactions with proteins of known function. The resulting co-structure and functional assignment may provide a starting point for a drug discovery effort.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalDrug Discovery Today
Volume13
Issue number3-4
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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