The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.

Yong Ding, Hanna Lapko, Ivan Ndamukong, Yuannan Xia, Ayed Al-Abdallat, Sreedevi Lalithambika, Monther Sadder, Abdelaty Saleh, Michael Fromm, Jean Jack Riethoven, Guoqing Lu, Zoya Avramova

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32 Scopus citations

Abstract

Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 regulates expression of a large number of genes; consequently, factors that affect ATX1 activity would also influence expression from ATX1-regulated genes. Here, we demonstrate that dehydration is such a factor implicating ATX1 in the plant's response to drought. In addition, we report that a hitherto unknown Arabidopsis gene, At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1). Myotubularin activities in plants have not been described and herein, we identify an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions. We propose that these shared genes represent the ultimate targets of partially overlapping branches of the pathways of the nuclear ATX1 and the cytoplasmic AtMTM1. Our analyses offer first genome-wide insights into the relationship of an epigenetic factor and a lipid phosphatase from the other end of a shared drought responding pathway in Arabidopsis.

Original languageEnglish (US)
Pages (from-to)1049-1058
Number of pages10
JournalPlant signaling & behavior
Volume4
Issue number11
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Plant Science

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    Ding, Y., Lapko, H., Ndamukong, I., Xia, Y., Al-Abdallat, A., Lalithambika, S., Sadder, M., Saleh, A., Fromm, M., Riethoven, J. J., Lu, G., & Avramova, Z. (2009). The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. Plant signaling & behavior, 4(11), 1049-1058. https://doi.org/10.4161/psb.4.11.10103