TY - JOUR
T1 - The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.
AU - Ding, Yong
AU - Lapko, Hanna
AU - Ndamukong, Ivan
AU - Xia, Yuannan
AU - Al-Abdallat, Ayed
AU - Lalithambika, Sreedevi
AU - Sadder, Monther
AU - Saleh, Abdelaty
AU - Fromm, Michael
AU - Riethoven, Jean Jack
AU - Lu, Guoqing
AU - Avramova, Zoya
PY - 2009/11
Y1 - 2009/11
N2 - Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 regulates expression of a large number of genes; consequently, factors that affect ATX1 activity would also influence expression from ATX1-regulated genes. Here, we demonstrate that dehydration is such a factor implicating ATX1 in the plant's response to drought. In addition, we report that a hitherto unknown Arabidopsis gene, At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1). Myotubularin activities in plants have not been described and herein, we identify an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions. We propose that these shared genes represent the ultimate targets of partially overlapping branches of the pathways of the nuclear ATX1 and the cytoplasmic AtMTM1. Our analyses offer first genome-wide insights into the relationship of an epigenetic factor and a lipid phosphatase from the other end of a shared drought responding pathway in Arabidopsis.
AB - Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 regulates expression of a large number of genes; consequently, factors that affect ATX1 activity would also influence expression from ATX1-regulated genes. Here, we demonstrate that dehydration is such a factor implicating ATX1 in the plant's response to drought. In addition, we report that a hitherto unknown Arabidopsis gene, At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1). Myotubularin activities in plants have not been described and herein, we identify an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions. We propose that these shared genes represent the ultimate targets of partially overlapping branches of the pathways of the nuclear ATX1 and the cytoplasmic AtMTM1. Our analyses offer first genome-wide insights into the relationship of an epigenetic factor and a lipid phosphatase from the other end of a shared drought responding pathway in Arabidopsis.
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U2 - 10.4161/psb.4.11.10103
DO - 10.4161/psb.4.11.10103
M3 - Article
C2 - 19901554
AN - SCOPUS:77954071305
VL - 4
SP - 1049
EP - 1058
JO - Plant Signaling and Behavior
JF - Plant Signaling and Behavior
SN - 1559-2316
IS - 11
ER -