The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

Marc van Bilsen, Hitesh C. Patel, Johann Bauersachs, Michael Böhm, Martin Borggrefe, Dirk Brutsaert, Andrew J.S. Coats, Rudolf A. de Boer, Gilles W. de Keulenaer, Gerasimos S. Filippatos, John Floras, Guido Grassi, Ewa A. Jankowska, Lilian Kornet, Ida G. Lunde, Christoph Maack, Felix Mahfoud, Piero Pollesello, Piotr Ponikowski, Frank RuschitzkaHani N. Sabbah, Harold D. Schultz, Petar Seferovic, Riemer H.J.A. Slart, Peter Taggart, Carlo G. Tocchetti, Linda W. Van Laake, Faiez Zannad, Stephane Heymans, Alexander R. Lyon

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Despite improvements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burdens on patients and health care systems worldwide. Alterations in autonomic nervous system (ANS) activity contribute to cardiac disease progression, and the recent development of invasive techniques and electrical stimulation devices has opened new avenues for specific targeting of the sympathetic and parasympathetic branches of the ANS. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop which brought together clinicians, trialists and basic scientists to discuss the ANS as a therapeutic target in HF. The questions addressed were: (i) What are the abnormalities of ANS in HF patients? (ii) What methods are available to measure autonomic dysfunction? (iii) What therapeutic interventions are available to target the ANS in patients with HF, and what are their specific strengths and weaknesses? (iv) What have we learned from previous ANS trials? (v) How should we proceed in the future?.

Original languageEnglish (US)
Pages (from-to)1361-1378
Number of pages18
JournalEuropean Journal of Heart Failure
Volume19
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • Autonomic dysfunction
  • Devices and nerve ablation
  • Heart failure
  • Parasympathetic
  • Sympathetic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    van Bilsen, M., Patel, H. C., Bauersachs, J., Böhm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G. W., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., ... Lyon, A. R. (2017). The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 19(11), 1361-1378. https://doi.org/10.1002/ejhf.921