The barrier to autointegration factor: Interlocking antiviral defense with genome maintenance

Matthew S. Wiebe; Augusta Jamin

doi:10.1128/JVI.00178-16

The barrier to autointegration factor: Interlocking antiviral defense with genome maintenance

Matthew S. Wiebe, Augusta Jamin

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.

Original language	English (US)
Pages (from-to)	3806-3809
Number of pages	4
Journal	Journal of virology
Volume	90
Issue number	8
DOIs	https://doi.org/10.1128/JVI.00178-16
State	Published - Apr 1 2016

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Access to Document

10.1128/JVI.00178-16

Fingerprint Dive into the research topics of 'The barrier to autointegration factor: Interlocking antiviral defense with genome maintenance'. Together they form a unique fingerprint.

Cite this

@article{84b9be0e84ad44c9aa9116eedb427c71,

title = "The barrier to autointegration factor: Interlocking antiviral defense with genome maintenance",

abstract = "Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.",

author = "Wiebe, {Matthew S.} and Augusta Jamin",

year = "2016",

month = apr,

day = "1",

doi = "10.1128/JVI.00178-16",

language = "English (US)",

volume = "90",

pages = "3806--3809",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - The barrier to autointegration factor

T2 - Interlocking antiviral defense with genome maintenance

AU - Wiebe, Matthew S.

AU - Jamin, Augusta

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.

AB - Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.

UR - http://www.scopus.com/inward/record.url?scp=84963811441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963811441&partnerID=8YFLogxK

U2 - 10.1128/JVI.00178-16

DO - 10.1128/JVI.00178-16

M3 - Article

C2 - 26842478

AN - SCOPUS:84963811441

VL - 90

SP - 3806

EP - 3809

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 8

ER -