The barrier to autointegration factor: Interlocking antiviral defense with genome maintenance

Matthew S. Wiebe, Augusta Jamin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.

Original languageEnglish (US)
Pages (from-to)3806-3809
Number of pages4
JournalJournal of virology
Volume90
Issue number8
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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