The biological role of death and lysis in biofilm development

Research output: Contribution to journalArticlepeer-review

279 Scopus citations


Recent studies have revealed that the regulated death of bacterial cells is important for biofilm development. Following cell death, a sub-population of the dead bacteria lyse and release genomic DNA, which then has an essential role in intercellular adhesion and biofilm stability. This Opinion focuses on the role of regulated cell death and lysis in biofilm development and provides a functional comparison between bacterial programmed cell death and apoptosis. The hypothesis that the differential regulation of these processes during biofilm development contributes to the antibiotic tolerance of biofilm cells is also explored.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalNature Reviews Microbiology
Issue number9
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Microbiology
  • General Immunology and Microbiology
  • Infectious Diseases


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