Abstract
Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5% fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11% fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.
Original language | English (US) |
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Pages (from-to) | 88-91 |
Number of pages | 4 |
Journal | Chemico-Biological Interactions |
Volume | 175 |
Issue number | 1-3 |
DOIs | |
State | Published - Sep 25 2008 |
Keywords
- Butyrylcholinesterase knockout mice
- Ghrelin
- Obesity
ASJC Scopus subject areas
- Toxicology