The butyrylcholinesterase knockout mouse is obese on a high-fat diet

Bin Li, Ellen G. Duysen, Oksana Lockridge

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5% fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11% fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalChemico-Biological Interactions
Volume175
Issue number1-3
DOIs
StatePublished - Sep 25 2008

Keywords

  • Butyrylcholinesterase knockout mice
  • Ghrelin
  • Obesity

ASJC Scopus subject areas

  • Toxicology

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