The c-Fes family of protein-tyrosine kinases

Thomas E. Smithgall, Jim A. Rogers, Kristi L. Peters, Jianze Li, Scott D. Briggs, Jack M. Lionberger, Haiyun Cheng, Annemarie Shibata, Beate Scholtz, Steven Schreiner, Nancy Dunham

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


The human c-fes protooncogene encodes a protein-tyrosine kinase (c-Fes) distinct from c-Src, cAbl and other nonreceptor tyrosine kinases. Although originally identified as the cellular homolog of several transforming retroviral oncoproteins, Fes was later found to exhibit strong expression in myeloid hematopoietic cells and to play a direct role in their differentiation. Recent work has shown that Fes exhibits a more widespread expression pattern in both developing and adult tissues, suggesting a general physiological function for this kinase and its closely related homolog, Fer. This review highlights the unique aspects of Fes structure, regulation, and function that set it apart from other tyrosine kinase families.

Original languageEnglish (US)
Pages (from-to)43-62
Number of pages20
JournalCritical Reviews in Oncogenesis
Issue number1
StatePublished - 1998


  • Coiled-coil
  • Differentiation
  • Fer
  • Fes
  • Fps
  • SH2
  • Tyrosine kinase

ASJC Scopus subject areas

  • Cancer Research


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