The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex

Yinbo Zhang; Andrey G. Baranovskiy; Tahir H. Tahirov; Youri I. Pavlov

doi:10.1074/jbc.M114.570333

The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex

Yinbo Zhang, Andrey G. Baranovskiy, Tahir H. Tahirov, Youri I. Pavlov

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background: DNA polymerase α-primase synthesizes chimeric RNA/DNA primers for replicative polymerases. Results: We defined elements that modulate polα and prim activities. Conclusion: The C-terminal domain of the catalytic subunit of polymerase α and the B-subunit regulate the priming of DNA replication. Significance: We provide new information on the regulation of RNA/DNA synthesizing complex that is indispensable for replication in eukaryotes.

Original language	English (US)
Pages (from-to)	22021-22034
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.570333
State	Published - Aug 8 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex. / Zhang, Yinbo; Baranovskiy, Andrey G.; Tahirov, Tahir H. et al.
In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22021-22034.

Research output: Contribution to journal › Article › peer-review

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AB - Background: DNA polymerase α-primase synthesizes chimeric RNA/DNA primers for replicative polymerases. Results: We defined elements that modulate polα and prim activities. Conclusion: The C-terminal domain of the catalytic subunit of polymerase α and the B-subunit regulate the priming of DNA replication. Significance: We provide new information on the regulation of RNA/DNA synthesizing complex that is indispensable for replication in eukaryotes.

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The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex

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