Abstract
Background: DNA polymerase α-primase synthesizes chimeric RNA/DNA primers for replicative polymerases. Results: We defined elements that modulate polα and prim activities. Conclusion: The C-terminal domain of the catalytic subunit of polymerase α and the B-subunit regulate the priming of DNA replication. Significance: We provide new information on the regulation of RNA/DNA synthesizing complex that is indispensable for replication in eukaryotes.
Original language | English (US) |
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Pages (from-to) | 22021-22034 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 32 |
DOIs | |
State | Published - Aug 8 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology