The capsaicinoids: Their separation, synthesis, and mutagenicity

Peter M. Gannett, Donald L. Nagel, Pam J. Reilly, Terence Lawson, Jody Sharpe, Bela Toth

Research output: Contribution to journalArticle

114 Scopus citations


Capsaicin (1b), the pungent ingredient in many varieties of Capsicums has recently been implicated as a possible carcinogen. When obtained from natural sources 1b is always accompanied by a number of related homologues. We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories. Also reported are mutagenicity data for lb and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.

Original languageEnglish (US)
Pages (from-to)1064-1071
Number of pages8
JournalJournal of Organic Chemistry
Issue number5
StatePublished - Mar 1 1988

ASJC Scopus subject areas

  • Organic Chemistry

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    Gannett, P. M., Nagel, D. L., Reilly, P. J., Lawson, T., Sharpe, J., & Toth, B. (1988). The capsaicinoids: Their separation, synthesis, and mutagenicity. Journal of Organic Chemistry, 53(5), 1064-1071.