The circular relationship between matrix metalloproteinase-9 and inflammation following myocardial infarction

Kristine Y. DeLeon-Pennell, Raffaele Altara, Andriy Yabluchanskiy, Alessandra Modesti, Merry L. Lindsey

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines and chemokines that stimulate MMP-9 production and release. In turn, MMP-9 proteolyzes cytokines and chemokines. Although in most cases, MMP-9 cleavage of the cytokine or chemokine substrate serves to increase activity, there are cases where cleavage results in reduced activity. Global MMP-9 deletion in mouse MI models has proven beneficial, suggesting inhibition of some aspects of MMP-9 activity may be valuable for clinical use. At the same time, overexpression of MMP-9 in macrophages has also proven beneficial, indicating that we still do not fully understand the complexity of MMP-9 mechanisms of action. In this review, we summarize the cycle of MMP-9 effects on cytokine production and cleavage to regulate leukocyte functions. Although we use MI as the example process, similar events occur in other inflammatory and wound healing conditions.

Original languageEnglish (US)
Pages (from-to)611-618
Number of pages8
JournalIUBMB Life
Issue number8
StatePublished - Aug 1 2015
Externally publishedYes


  • MMP
  • chemokines
  • cytokines
  • inflammation
  • myocardial infarction
  • proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology


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