TY - JOUR
T1 - The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26
AU - Allderdice, P. W.
AU - Gardner, H. A.R.
AU - Galutira, D.
AU - Lockridge, O.
AU - Ladu, B. N.
AU - McAlpine, P. J.
N1 - Funding Information:
Financial support for this project Research Council of Canada (MT6112, the Children’s Hospital of Winnipeg (P.J.M.), and NIH Grant GM27028 vided expert secretarial assistance. Note added in proof. Gaughan et al. (1991, regional localization was provided by the Medical P.J.M.; MT6725 P.W.A.), Research Foundation, Inc. (B.N.L.). M. Huebner pro-
PY - 1991/10
Y1 - 1991/10
N2 - Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown. An atypical form of butyrylcholinesterase or the absence of its activity leads to prolonged apnea following administration of the muscle relaxant suxamethonium. Inheritance of these butyrylcholinesterase variants is consistent with the enzyme activity being encoded in a single autosomal locus, BCHE (formerly CHE1 and E1), which has been assigned to chromosome 3. Previous in situ hybridization of a BCHE cDNA probe gave evidence of homologous sequences at 3q26 and 16q11-q23, raising the possibility of more than one locus coding for butyrylcholinesterase [H. Soreq, R. Zamir, D. Zevin-Sonkin, and H. Zakut (1987) Hum. Genet. 77: 325-328]. Using a different cDNA probe hybridized in situ to 46,XX,inv(3)(p25q21) metaphase chromosomes, we report here the localization of BCHE to a single autosomal location: 3q26.
AB - Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown. An atypical form of butyrylcholinesterase or the absence of its activity leads to prolonged apnea following administration of the muscle relaxant suxamethonium. Inheritance of these butyrylcholinesterase variants is consistent with the enzyme activity being encoded in a single autosomal locus, BCHE (formerly CHE1 and E1), which has been assigned to chromosome 3. Previous in situ hybridization of a BCHE cDNA probe gave evidence of homologous sequences at 3q26 and 16q11-q23, raising the possibility of more than one locus coding for butyrylcholinesterase [H. Soreq, R. Zamir, D. Zevin-Sonkin, and H. Zakut (1987) Hum. Genet. 77: 325-328]. Using a different cDNA probe hybridized in situ to 46,XX,inv(3)(p25q21) metaphase chromosomes, we report here the localization of BCHE to a single autosomal location: 3q26.
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U2 - 10.1016/0888-7543(91)90154-7
DO - 10.1016/0888-7543(91)90154-7
M3 - Article
C2 - 1769657
AN - SCOPUS:0026000701
SN - 0888-7543
VL - 11
SP - 452
EP - 454
JO - Genomics
JF - Genomics
IS - 2
ER -