@article{1672a2be3c7e47eaa3f91bda63aca043,
title = "The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus",
abstract = "RsaE is a regulatory RNA highly conserved amongst Firmicutes that lowers the amount of mRNAs associated with the TCA cycle and folate metabolism. A search for new RsaE targets in Staphylococcus aureus revealed that in addition to previously described substrates, RsaE down-regulates several genes associated with arginine catabolism. In particular, RsaE targets the arginase rocF mRNA via direct interactions involving G-rich motifs. Two duplicated C-rich motifs of RsaE can independently downregulate rocF expression. The faster growth rate of rsaE compared to its parental strain in media containing amino acids as sole carbon source points to an underlying role for RsaE in amino acid catabolism. Collectively, the data support a model in which RsaE acts as a global regulator of functions associated with metabolic adaptation.",
author = "Tatiana Rochat and Chantal Bohn and Claire Morvan and {Le Lam}, {Thao Nguyen} and Fareha Razvi and Adrien Pain and Claire Toffano-Nioche and Prishila Ponien and Annick Jacq and Eric Jacquet and Fey, {Paul D.} and Daniel Gautheret and Philippe Bouloc",
note = "Funding Information: Agence Nationale pour la Recherche [ANR-2012-BLAN-1602 (Duplex-Omics); ANR-15-CE12-0003 (sRNA-Fit)]; Fondation pour la Recherche M{\'e}dicale [DBF20160635724]; National Institutes of Health [NIH/NIAID P01AI083211]. Funding for open access charge: Agence Nationale pour la Recherche [ANR-15-CE12-0003]. Conflict of interest statement. None declared. Funding Information: Agence Nationale pour la Recherche [ANR-2012-BLAN-1602 (Duplex-Omics); ANR-15-CE12-0003 (sRNA-Fit)]; Fondation pour la Recherche M{\'e}dicale [DBF20160635724]; National Institutes of Health [NIH/NIAID P01AI083211]. Funding for open access charge: Agence Nationale pour la Recherche [ANR-15-CE12-0003]. Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.",
year = "2018",
month = sep,
day = "28",
doi = "10.1093/nar/gky584",
language = "English (US)",
volume = "46",
pages = "8803--8816",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "17",
}