TY - JOUR
T1 - The control of death and lysis in staphylococcal biofilms
T2 - A coordination of physiological signals
AU - Sadykov, Marat R.
AU - Bayles, Kenneth W.
N1 - Funding Information:
We thank Vinai Chittezham Thomas and Kari Nelson for their useful comments and suggestions. This research was supported by grants P01-AI083211 and R01-A1038901 from the National Institutes of Health .
PY - 2012/4
Y1 - 2012/4
N2 - The processes involved in the development of complex multicellular communities, including the programmed elimination of individual cells during the formation of specialized structures, exhibit fundamental similarities between prokaryotic and eukaryotic organisms. Mechanistic similarities may also exist at the molecular level, as bacterial proteins hypothesized to be related to the apoptosis regulator Bax/Bcl-2 family have been identified, fueling speculation about the existence of bacterial PCD. Here we review the regulatory networks controlling cell death and lysis in Staphylococcus aureus and examine the environmental parameters that might influence them during the development of a biofilm. We hypothesize that the heterogeneous environmental conditions found within a developing biofilm generate distinct physiological signals that coordinate the differential expression of cell death and lysis effectors.
AB - The processes involved in the development of complex multicellular communities, including the programmed elimination of individual cells during the formation of specialized structures, exhibit fundamental similarities between prokaryotic and eukaryotic organisms. Mechanistic similarities may also exist at the molecular level, as bacterial proteins hypothesized to be related to the apoptosis regulator Bax/Bcl-2 family have been identified, fueling speculation about the existence of bacterial PCD. Here we review the regulatory networks controlling cell death and lysis in Staphylococcus aureus and examine the environmental parameters that might influence them during the development of a biofilm. We hypothesize that the heterogeneous environmental conditions found within a developing biofilm generate distinct physiological signals that coordinate the differential expression of cell death and lysis effectors.
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U2 - 10.1016/j.mib.2011.12.010
DO - 10.1016/j.mib.2011.12.010
M3 - Review article
C2 - 22221897
AN - SCOPUS:84861832830
SN - 1369-5274
VL - 15
SP - 211
EP - 215
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 2
ER -