The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

Samantha D. Francis Stuart, Nicole M. De Jesus, Merry L. Lindsey, Crystal M. Ripplinger

Research output: Contribution to journalReview articlepeer-review

170 Scopus citations


Optimal healing of damaged tissue following myocardial infarction (MI) requires a coordinated cellular response that can be divided into three phases: inflammatory, proliferative/reparative, and maturation. The inflammatory phase, characterized by rapid influx of cytokines, chemokines, and immune cells, is critical to the removal of damaged tissue. The onset of the proliferative/reparative phase is marked by increased proliferation of myofibroblasts and secretion of collagen to replace dead tissue. Lastly, crosslinking of collagen fibers and apoptosis of immune cells marks the maturation phase. Excessive inflammation or fibrosis has been linked to increased incidence of arrhythmia and other MI-related pathologies. This review describes the roles of inflammation and fibrosis in arrhythmogenesis and prospective therapies for anti-arrhythmic treatment.

Original languageEnglish (US)
Pages (from-to)114-122
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
StatePublished - Feb 1 2016
Externally publishedYes


  • Arrhythmia
  • Fibrosis
  • Inflammation
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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