The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease

Raju Lama Tamang, Anthony F. Juritsch, Rizwan Ahmad, Jeffrey D Salomon, Punita Dhawan, Amanda E. Ramer-Tait, Amar Bahadur Singh

Research output: Contribution to journalReview articlepeer-review

Abstract

The intestinal barrier orchestrates selective permeability to nutrients and metabolites while excluding noxious stimuli. Recent scientific advances establishing a causal role for the gut microbiota in human health outcomes have generated a resurgent interest toward intestinal permeability. Considering the well-established role of the gut barrier in protection against foreign antigens, there is mounting evidence for a causal link between gut permeability and the microbiome in regulating human health. However, an understanding of the dynamic host–microbiota interactions that govern intestinal barrier functions remains poorly defined. Furthermore, the system-level mechanisms by which microbiome-targeted therapies, such as probiotics and prebiotics, simultaneously promote intestinal barrier function and host health remain an area of active investigation. This review summarizes the recent advances in understanding the dynamics of intestinal permeability in human health and its integration with gut microbiota. We further summarize mechanisms by which probiotics/prebiotics influence the gut microbiota and intestinal barrier functions.

Original languageEnglish (US)
Article number2077069
JournalTissue Barriers
DOIs
StateAccepted/In press - 2022

Keywords

  • diet
  • Gut barrier
  • gut permeability
  • microbiota
  • Probiotics

ASJC Scopus subject areas

  • Biochemistry
  • Histology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease'. Together they form a unique fingerprint.

Cite this