The direction of apomorphine-induced rotation behavior is dependent on the location of excitotoxin in the rat basal ganglia

Andrew B. Norman, Robert B. Norgren, Lindy M. Wyatt, Jeffrey P. Hildebrand, Paul R. Sanberg

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Adult rats received unilateral kainic acid (KA) lesions of the striatum with the anterior/posterior coordinates of the lesion at either 1.5 mm or 0.3 mm anterior to bregma. Four to six weeks after the lesion rats were placed in an open field environment and injected with apomorphine (1 mg/kg, s.c). Rats receiving the more posterior lesion (0.3 mm) rotated ipsilateral to the lesioned side of the brain. In contrast, the majority of rats receiving the more anterior (1.5 mm) placement of the lesion rotated contralateral to the lesioned side of the brain. Histological analysis of several animals receiving posterior lesions revealed damage to the hippocampus and thalamus that was not seen in the animals receiving anterior lesions. Our results are consistent with the hypothesis that the direction of apomorphine-induced rotation after excitotoxin injection into the rat basal ganglia is dependent on the location of the lesion.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalBrain Research
Volume569
Issue number1
DOIs
StatePublished - Jan 8 1992

Keywords

  • Dopamine receptor
  • Excitotoxin
  • Hippocampus
  • Rotation behavior
  • Striatum
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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