The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position

Jeremy I. Levin; Mila T. Du; John F. DiJoseph; Loran M. Killar; Amy Sung; Thomas Walter; Michele A. Sharr; Catherine E. Roth; Franklin J. Moy; Robert Powers; Guixian Jin; Rebecca Cowling; Jerauld S. Skotnicki

doi:10.1016/S0960-894X(00)00642-9

The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position

Jeremy I. Levin, Mila T. Du, John F. DiJoseph, Loran M. Killar, Amy Sung, Thomas Walter, Michele A. Sharr, Catherine E. Roth, Franklin J. Moy, Robert Powers, Guixian Jin, Rebecca Cowling, Jerauld S. Skotnicki

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.

Original language	English (US)
Pages (from-to)	235-238
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00642-9
State	Published - Jan 22 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00642-9

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Levin, J. I., Du, M. T., DiJoseph, J. F., Killar, L. M., Sung, A., Walter, T., Sharr, M. A., Roth, C. E., Moy, F. J., Powers, R., Jin, G., Cowling, R., & Skotnicki, J. S. (2001). The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position. Bioorganic and Medicinal Chemistry Letters, 11(2), 235-238. https://doi.org/10.1016/S0960-894X(00)00642-9

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author = "Levin, {Jeremy I.} and Du, {Mila T.} and DiJoseph, {John F.} and Killar, {Loran M.} and Amy Sung and Thomas Walter and Sharr, {Michele A.} and Roth, {Catherine E.} and Moy, {Franklin J.} and Robert Powers and Guixian Jin and Rebecca Cowling and Skotnicki, {Jerauld S.}",

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AU - Killar, Loran M.

AU - Sung, Amy

AU - Walter, Thomas

AU - Sharr, Michele A.

AU - Roth, Catherine E.

AU - Moy, Franklin J.

AU - Powers, Robert

AU - Jin, Guixian

AU - Cowling, Rebecca

AU - Skotnicki, Jerauld S.

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The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position

Abstract

ASJC Scopus subject areas

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