The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position

Jeremy I. Levin, Mila T. Du, John F. DiJoseph, Loran M. Killar, Amy Sung, Thomas Walter, Michele A. Sharr, Catherine E. Roth, Franklin J. Moy, Robert Powers, Guixian Jin, Rebecca Cowling, Jerauld S. Skotnicki

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number2
DOIs
StatePublished - Jan 22 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Levin, J. I., Du, M. T., DiJoseph, J. F., Killar, L. M., Sung, A., Walter, T., Sharr, M. A., Roth, C. E., Moy, F. J., Powers, R., Jin, G., Cowling, R., & Skotnicki, J. S. (2001). The discovery of anthranilic aci-based MMP inhibitors. Part 1: SAR of the 3-position. Bioorganic and Medicinal Chemistry Letters, 11(2), 235-238. https://doi.org/10.1016/S0960-894X(00)00642-9