The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography

Daniel T. Monaghan, Carl W. Cotman

Research output: Contribution to journalArticlepeer-review

385 Scopus citations

Abstract

The distribution of [3H]kainic acid (KA) binding sites in the rat CNS was determined by in vitro autoradiography. KA sites are distributed throughout the CNS gray matter in an anatomically specific pattern with telencephalic structures and the cerebellum accounting for the majority of the binding. These results, together with our previous finding that KA sites are greatly enriched at the synapse, suggest that KA binding sites are associated with select terminal fields, and hence may be involved in neurotransmission in certain CNS pathways.

Original languageEnglish (US)
Pages (from-to)91-100
Number of pages10
JournalBrain Research
Volume252
Issue number1
DOIs
StatePublished - Dec 2 1982

Keywords

  • excitatory amino acids
  • kainic acid
  • receptor autoradiography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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