The effect of age on methacholine response

Russell J. Hopp, Againdra Bewtra, Nicki M. Nair, Robert G. Townley

Research output: Contribution to journalArticlepeer-review

161 Scopus citations


Bronchial reactivity to inhaled methacholine exists in subjects with asthma but may occur in subjects with allergic rhinitis, chronic lung diseases, and during respiratory infections. In the absence of these factors, we found that age also has a significant effect on the methacholine response. One hundred forty-eight subjects, 5 to 76 years of age, were studied as normal control subjects in a natural history of asthma study. The methacholine response was measured by standard techniques. The analysis demonstrated that age had a significant effect on the methacholine response. In addition to known factors influencing the results of methacholine inhalation, young and older subjects may exhibit bronchial responses that may falsely suggest hyperreactive airway disease.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Issue number4
StatePublished - Oct 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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