The effect of aldose reductase and its inhibition on sugar cataract formation

Peter F. Kador, Yoshio Akagi, Jin H. Kinoshita

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Cataracts associated with diabetes and galactosemia are characterized by their rapid onset and bilateral appearance. These cataracts display similar morphology and histology and have common biochemical mechanisms initiating the cataractous processes. An understanding of these biochemical mechanisms has been aided both by the ability to reproduce these cataracts in various animal models and by the development of potent inhibitors of aldose reductase. This is a US government work. There are no restrictions on its use.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalMetabolism
Volume35
Issue number4 SUPPL. 1
DOIs
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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