The effect of continuous salt infusion on blood pressure in the Rhesus monkey ( mulatto)

M. S. Olguin, A. D. Werth, K. G. Cornish

Research output: Contribution to journalArticlepeer-review


A study was conducted to show the correlation between salt loading and hypertension in the Rhesus monkey. Four monkeys were used and their mean systemic blood pressures (MSBP) monitored continuously during a 3 week acclimation period, at which time a baseline MSBP was established. The baseline MSBP's were 82.5mmHg, 80.80mmHg, 101.02mmHg, and 96.39mmHg for each of the four monkeys respectively. A salt infusion was administered via a right atria) catheter. Two monkeys were placed on a high salt infusion of 14.29mEq/kg/day (monkeys 1 and 4), while the other two were on a low salt infusion of 8.57mEo/kg/day (monkeys 2 and 3). Data were collected and analyzed, calculating a daily average MSBP for each monkey The MSBP's of the monkeys at the end of the study were 81 26mmHg, 81.82mmHg, 8771mmHg, and 93.98mmHg respectively. Two of the monkeys were removed from the study (monkey 3 at 7 months, and monkey 4 at 5 1/2 months) due to complications. Monkeys 1 and 2 were on the study for 7 months each. Sodium excretion was determined daily from urinary sodium excretion. Urine sodium excretion directly correlated with the amount of sodium infused. The monkeys in this study were not salt sensitive suggesting that salt sensitivity plays a significant rote in development of hypertension. These data do not support the hypothesis that salt loading leads to hypertension.

Original languageEnglish (US)
Pages (from-to)A632
JournalFASEB Journal
Issue number3
StatePublished - 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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