The effect of cyclophosphamide administration on the kidney of the rat

Okamura Takehiko, Emily M. Garland, Rodney J. Taylor, Sonny L. Johansson, Samuel M. Cohen

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyelophosphamide-induced hemorrhagic cystitis in the rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild renal changes. The combination of cyclophosphamide and intravesical instillation of acetic acid induced renal papillary necrosis (38 to 83% incidence) along with pyelonephritis, hydroureter and hydronephrosis. Chitosan, instilled in place of acetic acid, partially inhibited the induction of renal papillary necrosis. It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage.

Original languageEnglish (US)
Pages (from-to)261-276
Number of pages16
JournalToxicology Letters
Volume63
Issue number3
DOIs
StatePublished - Dec 1992

Keywords

  • Cyclophosphamide
  • Hemorrhagic cystitis
  • Hydronephrosis
  • Papillary necrosis
  • Renal toxicity

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'The effect of cyclophosphamide administration on the kidney of the rat'. Together they form a unique fingerprint.

  • Cite this