The effect of cyclophosphamide administration on the kidney of the rat

Okamura Takehiko; Emily M. Garland; Rodney J. Taylor; Sonny L. Johansson; Samuel M. Cohen

doi:10.1016/0378-4274(92)90089-3

The effect of cyclophosphamide administration on the kidney of the rat

Okamura Takehiko, Emily M. Garland, Rodney J. Taylor, Sonny L. Johansson, Samuel M. Cohen

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyelophosphamide-induced hemorrhagic cystitis in the rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild renal changes. The combination of cyclophosphamide and intravesical instillation of acetic acid induced renal papillary necrosis (38 to 83% incidence) along with pyelonephritis, hydroureter and hydronephrosis. Chitosan, instilled in place of acetic acid, partially inhibited the induction of renal papillary necrosis. It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage.

Original language	English (US)
Pages (from-to)	261-276
Number of pages	16
Journal	Toxicology Letters
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(92)90089-3
State	Published - Dec 1992

Keywords

Cyclophosphamide
Hemorrhagic cystitis
Hydronephrosis
Papillary necrosis
Renal toxicity

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(92)90089-3

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title = "The effect of cyclophosphamide administration on the kidney of the rat",

abstract = "In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyelophosphamide-induced hemorrhagic cystitis in the rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild renal changes. The combination of cyclophosphamide and intravesical instillation of acetic acid induced renal papillary necrosis (38 to 83% incidence) along with pyelonephritis, hydroureter and hydronephrosis. Chitosan, instilled in place of acetic acid, partially inhibited the induction of renal papillary necrosis. It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage.",

keywords = "Cyclophosphamide, Hemorrhagic cystitis, Hydronephrosis, Papillary necrosis, Renal toxicity",

author = "Okamura Takehiko and Garland, {Emily M.} and Taylor, {Rodney J.} and Johansson, {Sonny L.} and Cohen, {Samuel M.}",

note = "Funding Information: We gratefullya cknowledgeM argaret St. John, Curt Forst, Jan M. Wehner, and Dr. Tsuneo Masui for their assistancwe ith this experimentD, r. K. Patil and Moha-mad Khachab for statisticaal nalysesa, nd DeborahaC olemanf or assistancein the preparationo f this manuscriptT. his researcwh as supportedin part by a grantf rom HoechstC o.",

year = "1992",

month = dec,

doi = "10.1016/0378-4274(92)90089-3",

language = "English (US)",

volume = "63",

pages = "261--276",

journal = "Toxicology Letters",

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AU - Takehiko, Okamura

AU - Garland, Emily M.

AU - Taylor, Rodney J.

AU - Johansson, Sonny L.

AU - Cohen, Samuel M.

N1 - Funding Information: We gratefullya cknowledgeM argaret St. John, Curt Forst, Jan M. Wehner, and Dr. Tsuneo Masui for their assistancwe ith this experimentD, r. K. Patil and Moha-mad Khachab for statisticaal nalysesa, nd DeborahaC olemanf or assistancein the preparationo f this manuscriptT. his researcwh as supportedin part by a grantf rom HoechstC o.

PY - 1992/12

Y1 - 1992/12

N2 - In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyelophosphamide-induced hemorrhagic cystitis in the rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild renal changes. The combination of cyclophosphamide and intravesical instillation of acetic acid induced renal papillary necrosis (38 to 83% incidence) along with pyelonephritis, hydroureter and hydronephrosis. Chitosan, instilled in place of acetic acid, partially inhibited the induction of renal papillary necrosis. It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage.

AB - In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyelophosphamide-induced hemorrhagic cystitis in the rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild renal changes. The combination of cyclophosphamide and intravesical instillation of acetic acid induced renal papillary necrosis (38 to 83% incidence) along with pyelonephritis, hydroureter and hydronephrosis. Chitosan, instilled in place of acetic acid, partially inhibited the induction of renal papillary necrosis. It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage.

KW - Cyclophosphamide

KW - Hemorrhagic cystitis

KW - Hydronephrosis

KW - Papillary necrosis

KW - Renal toxicity

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JO - Toxicology Letters

JF - Toxicology Letters

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ER -

The effect of cyclophosphamide administration on the kidney of the rat

Abstract

Keywords

ASJC Scopus subject areas

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